The year 2013 brought signs of a gratifying maturation in autism research. This went beyond the unmistakable increase in the sheer number of autism studies making headlines. Many of the year’s most important advances used new technologies and built on the foundation of knowledge established by years of investment in basic research. Increasingly, we saw a shift toward research projects that delivered concrete advances in the prevention, diagnosis and personalized treatment of autism and its associated medical conditions. This progress also reflected the growing appreciation that, for some individuals, autism is a whole-body disorder.