In Children With ADHD Methylphenidate 'Normalizes' Activation In Key Brain Areas

The stimulant drug methylphenidate "normalizes" activation of several brain areas in young patients with attention-deficit/hyperactivity disorder (ADHD), according to a review published in the May Harvard Review of Psychiatry. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.  Studies using functional magnetic resonance imaging (fMRI) show increased activation of key brain areas after a dose of methylphenidate in young patients with ADHD, according to the systematic review by Constance A. Moore, PhD, and colleagues of the University of Massachusetts Medical School. They write, "In most cases, this increase 'normalized' activation of at least some brain areas to levels seen in typically developing children."

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